Bill Murray reflected on his early 2000s romantic comedy-drama Lost in Translation on The Drew Barrymore Show this week — and left the host speechless.

The Caddyshack actor, 74, appeared on Barrymore’s talk show on Wednesday, March 12, to talk about his movie Riff Raff, but that wasn’t before reminiscing on his 2003 film, Lost in Translation.

“Well there was a girl, she was a teenager back then her name was Scarlett Johansson back then,” the comedian told Barrymore, 50. “She was only 17 when she made that movie, 17 years old and it was beautiful to make the movie with the two of them [director Sofia Coppola and Johansson].”

Barrymore wasted no time in asking the lead actor, who played Bob Harris, about the unforgettable whispering scene with Johansson’s character Charlotte at the end of the film.

“I feel like another person in the annoying line,” the daytime talk show host admitted to Murray while inquiring exactly what was said between the two stars.

“You are going right to the head of the annoying line,” Murray joked.

Barrymore, leaning forward during the entirety of the interview in anticipation, said she will never cease to wonder at the scene.

“I love that you guys had the confidence to leave the film on the note of mystery,” Barrymore told Murray.

“Well that was an inspired moment, that happened in the moment, it happened in the moment,” Murray said before continuing, “there were three of us that had the same moment.”

Murray reenacted how Coppola looked at him, before he gave a slight nod to her. Meanwhile, the script supervisor Eva Z. Cabrera, whom Murray describes as a “toughie,” looked over and said during the scene, “‘You don’t have to say a thing.’”

“That was a moment of seeing, ‘This is going to happen and it’s going to be even better because we’re never going to know,’ ” Murray told Barrymore about the iconic scene. 

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Barrymore asked excitedly if Murray had actually whispered something into Johansson’s ear, to which the comedian reenacted the scene, leaning over and whispering into Barrymore’s ear. This left the audience screaming and clapping. 

The 50 First Dates actress pressed her lips together, looking up to the sky visibly relishing in the moment. “Thank you, Bill,” Barrymore said after gathering herself.  

In 2021, when Murray was honored with the Maltin Modern Master Award at the 36th Annual Santa Barbara International Film Festival, he spoke of his deep appreciation for the film’s director, Coppola.

“Well, I love Sofia. It’s great because the longer I know her the more I love her and the more I get to love. I see that she’s a real American woman,” he said in PEOPLE’s exclusive clip of his conversation for the award, which honors an individual who has enriched culture through accomplishments in the motion picture industry.

“A working mother, and an artist, and a sister, and a wife. She’s all those things and I am none of those things, so it’s kind of fun. I completely get to give myself up to it. I can really admire all things because I am not,” the actor continued.

Johansson spoke to Gwyneth Paltrow on an episode of her Goop podcast about unexpectedly running into her former costar Murray 10-plus years after they filmed their 2003 hit.

“I didn’t see him for a decade or more. It was a long time,” Johansson began. “And then I walked into a bar with my ex-boyfriend from a long time ago … and there was only one person at the bar and it was Bill Murray.”

“It had been a decade of time, more than a decade of time. [I was] like ‘All right, I guess I’ll have to go and see what’s up.’ “