When it comes to roles he’s played over the course of his career, Matthew Lillard thinks that Scream villain Ghostface would be no match for another iconic character: Shaggy in Scooby-Doo.

During a panel discussion at MegaCon in Orlando, Fla., last month, Lillard was asked how Shaggy (who he played in the 2002 and 2004 live-action Scooby-Doo films) would fare in a Scream movie.

“[Shaggy] would 100% kick ass, ‘cause he would literally look at the first dead person and run for days,” Lillard, 55, said. “He would do what every normal person would do, which is like, ‘I’m out! I don’t wanna be here! I don’t need to save anyone else. I’m leaving.’ ”

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Elsewhere in the panel, Lillard reflected on his time in the 1996 slasher film with fellow cast member Skeet Ulrich.

Acting in the original film — which featured a number of Hollywood up-and-comers, including Neve Campbell, Rose McGowan and Jamie Kennedy — was, he said, “my experience of what college would be like.”

“We were a bunch of kids running around Santa Rosa. We worked 6 p.m. to basically 8 a.m., so we’d come off of work, and we’d all go to David Arquette’s room and drink like fools. And we were young. It was a pivotal moment in all of our lives; it changed our lives. And we’re all friends to this day. So it’s a college experience,” he added.

Ulrich echoed the sentiment, noting that none of the cast or crew had any idea that the low-budget ’90s film would become such a cultural phenomenon. 

“We were a bunch of kids trying to, you know, break into the business in a bigger way,” the Riverdale actor, 55, said, adding, “We were really a bunch of actors who got together and took a chance on a film that even Hollywood didn’t necessarily want to take a chance on.”

Lillard also confirmed that he will be making an appearance in the upcoming Scream 7, slated for release in February 2026.

“I’ve been asked literally 1,000 times a day since the first movie ended if I’m coming back. And I’m happy to report I am,” he said.