[PRESS RELEASE – Panama City, Panama, April 16th, 2025]

PoSciDonDAO, a decentralized organization dedicated to advancing scientific research, has approved its first-ever research funding proposal following the launch of its governance platform on March 19. The proposal, submitted by the Rare Compute Foundation, was made available to the DAO community for a vote and has successfully passed the quorum with majority support. It will be the first research project funded directly by PoSciDonDAO.

The approved project focuses on the application of generative artificial intelligence for the design of new treatments targeting rare diseases. The Rare Compute Foundation will receive 115,000 USDC on the Base network to carry out the proposed work. The effort integrates high-performance computing, machine learning, and laboratory experimentation in what the team describes as a “wet-dry loop”. The dry lab involves using computers and AI to design possible new medicines, which will then be tested in the wet lab setting for biological validation at university partners.

The research will develop and test three classes of molecular agents: small molecules, small proteins, and macromolecular binders such as antibodies. The team will first focus on diseases linked to the brain, especially those related to memory loss and problems with proteins building up in brain cells. Later, they may also work on pediatric oncology and autoimmune diseases.

Deliverables from the project include therapeutic candidate molecules, open-access and peer-reviewed publications, and machine learning models that may be released through public repositories or distributed through controlled-access systems. Among the tools expected are specialized models for blood-brain barrier permeability prediction and molecular design frameworks tailored to rare disease targets.

The project will be carried out in two phases. The first, a three-month “dry lab” period, will focus on data curation, model training, and candidate generation. A subsequent wet lab phase will involve experimental validation and refinement of selected candidates. The team has committed to providing regular financial reporting and weekly updates to PoSciDonDAO contributors.

This marks an important step for PoSciDonDAO and for the idea of decentralized science, demonstrating the organization’s capacity to support scientific research through decentralized decision-making and treasury management. It shows that communities can work together to choose and fund research that could help people with serious and often overlooked health problems.

About PoSciDonDAO

PoSciDonDAO leverages blockchain technology to democratize personalized medicine research by bridging the gap between researchers, funders, and the broader scientific community. Through decentralized governance and funding, the platform ensures transparent and equitable resource allocation, fostering trust and inclusivity in advancing personalized medicine innovation.

For more information about PoSciDonDAO, users can visit the official PoSciDonDAO website.

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